
01
Lith
Hepit, Void (Capture Mission)
Run Hepit Void for quick lith relic farming. Very short mission, just take down the target and capture them, head to extract. These missions also drop Aya (Prime Resurgence Currency).
Mission Rewards give you the relic, use a matching void fissure mission to crack open the relic. Refine if you need a rare reward.
Here are the quickest missions that you can go to, to farm the relics. However clicking on the detailed pages will give you in depth details and odds of each relic.

01
Hepit, Void (Capture Mission)
Run Hepit Void for quick lith relic farming. Very short mission, just take down the target and capture them, head to extract. These missions also drop Aya (Prime Resurgence Currency).

02
Ukko, Void (Capture Mission)
Another Capture Mission, get a fast frame and complete the mission to get a Meso or Neo Relic. If you strictly want to target Meso Farm, then go for Olympus or look at the detailed drop tables.
Reward
Meso or Neo Relic, with Aya in the same reward pool
50% Meso, 43.75% Neo, 6.25% Aya
Compare Meso farms
03
Ukko Void (Capture) or Ur, Uranus (Disruption)
Ukko Void offers both Neo and Meso. But if you want to target farm Neo, Rotation B on Ur, Uranus has a 100% drop chance.
Reward
Meso or Neo Relic, with Aya in the same reward pool
43.75% Neo, 50% Meso, 6.25% Aya
Compare Neo farms
04
Apollo, Lua (Disruption)
Usually the higher tier or rarer items for each prime are tied to Axi Relics. Apollo Lua Disruption mission is the best axi farm at the moment. Use the 4-3-2-1 plan: kill 4 demolishers in round 1, 3 in round 2, 2 in round 3, then 1 from round 4 onward.
Reward
Axi Relic on Rotation B or most Rotation C outcomes
100% Axi on Rotation B, 86.94% Axi on Rotation C
Compare Axi farms
05
Kuva Flood and Kuva Siphon missionsKuva Flood/Siphon
Farm Requiem Eterna when you need Requiem Mods for Kuva Liches or Sisters of Parvos.
A Relic has multiple rewards, three common, two uncommon and one rare. You can shift the odds towards your favour through the relic refinement system. You need Void Traces for this.
Always run four player radiant share for relics that contain rare items. Four matching relics + all 4 radiant means the squad has a 34.39% chance of getting the rare reward.
3 of 6 rewards
2 of 6 rewards
1 of 6 rewards
2% rare chance
Your vanilla relic. If you want common items, and want to farm ducats.
4% rare chance
For Uncommon Rewards.
6% rare chance
Middle ground for uncommon to rare.
10% rare chance
Best rare chance. Always run these with a squad as it costs 100 traces.
Choose a tier to find its relics, farming routes, and reward tables.
Pick a frame or weapon and see which relics contain each required part.
Record owned relics and build a farming plan without leaving the site.
Find relics that have left normal mission rewards and review their contents.
See which vaulted Prime gear has returned and where Aya fits into the farm.
Check the current release and the Prime gear that arrived with it.
Best Relics to Farm as per their tier is: Hepit, Void (Capture) for Lith Relics, Ukko for quick Meso and Neo. For Axi Relics, Apollo on Lua with the Disruption Rotation trick.
Collecting 10 Reactants during your Relic opening missions will net you random amounts of these. You can boost this number with a resource booster, and you also get a bonus if someone from the team picks the reward from your relic.
It only makes sense to refine a relic to radiant when you're after the rare part. A squad rad-share increases the chance of getting the reward to 34.39% instead of 10% when you run solo.
Unvaulted relics are the relics that you can still farm in the game. Vaulted relics are retired relics that do not drop anymore, to obtain them you need to trade with other players or wait for the correct Prime Resurgence rotation.